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Klinikum Großhadern
University of Munich, Germany
April 9-12, 2008

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Details
Wednesday, April 9th: Hotel Eden Wolff

  Program
10:00 – 18:00 Continuous Registration
11:00 – 13:00 Salon Engadin ESHO Council Meeting
11:00 – 13:00 Salon Prinz Eugen STM Council Meeting
11:00 – 13:00 Salon Maria Theresia ASHO Board Meeting
13:00 – 14:15 Rembrandt Zimmer International Journal of Hyperthermia Board Meeting
14:30 – 15:30 Rembrandt Zimmer IAHO Meeting
  Opening Ceremony
16:30 – 17:00 Europasaal Welcome remarks
R.D. Issels – ICHO2008 Congress President
T. Goppel - Bavarian Minister for Science, Research and the Arts, via Video
M. Hurzwitz, President Elect STM
T. Ohnishi, President ASHO
17:00 – 17:15 Music
17:15 – 18:00   Key Note Lecture
Alexander Eggermont: Translational Research is Mandatory in Clinical Research
18:00 – 18:30 Break
18:30 – 19:00   Presentation IAHO Award
Tsutomu Sugahara: Twenty years of clinical hyperthermia since the 5th ICHO in Kyoto
19:00 – 19:30   IAHO Award
Chang Song: Mild hyperthermia is the most powerful mean to overcome hypoxic protection in cancer treatment.
from 19:30 Edensaal Welcome Reception

Details
Thursday, April 10th: Klinikum Grosshadern – Lecture Halls

7:45-8:30 QA Workshop
Chair: T. Kondo (J), T. Ohnishi (J)
Lecture room I
  Session I A – Thursday 08.30 – 10.00 Lecture room VI Session I B – Thursday 8.30 – 10.00 Lecture room V
Time Biology: Heat shock proteins in Medicine

Chair: T. Kondo (J), T. Ohnishi (J)
Perfusion Techniques

Chair: KW Jauch (D)
8:30 – 10:00 K. Ohtsuka (J)
Molecular chaperone activity of Hsp70 and Hsp40, and its medical application (15 mins)
T. Kondo (J)
Genes and genetic networks responsive to mild hyperthermia in human leukemia U937 cells (15 mins)
A. Takahashi (J)
The study of target genes deciding heat-sensitivity (15 mins)
T. Ohnishi (J)
Localization of DSB-recognizing proteins in the nucleus after heat treatment (15 mins)
A. Laszlo (USA)Heat-induced perturbations of the DNA damage response play a role in heat radiosensitization (15 mins)
J. Haveman (NL)
Chromosome fragments have the potential to predict hyperthermia-induced radiosensitization in two different human tumor cell lines. (15 mins)
A. Eggermont (NL)
TNF-isolated limb perfusion for extremity soft tissue sarcomas (35 mins)
C. Graeb (D)
HIPEC for peritoneal carcinomatosis of gastrointestinal cancer (35 mins)
T. Meier (D)
Learning curve for 'closed' hyperthermic intraperitoneal chemotherapy due to peritoneal surface malignancies (20 mins)
10.00 – 10:30 Coffee Break
  Session II A – Thursday 10.30 – 12.00 Lecture room VI Session II B – Thursday 10.30 – 12.00 Lecture room V
  Immunology I

Chair: S. Calderwood (USA), G. Multhoff (D)
Treatment planning and Image Guided Therapy II

Chair: J. Lagendijk (NL), S. Das (USA)
10:30 – 12:00 W. Van Eden (NL)
Heat shock proteins induce T-cell regulation of chronic inflammation (20 mins)
S. Calderwood (USA)
Role of scavenger receptors in Hsp70-based immunotherapy (20 mins)
A. Asea (USA)
Hsp25 Silencing (15 mins)
G. Multhoff (D)
Hsp70 and HLA-E serve as activatory and inhibitory ligands for CD94 positive NK cells (15 mins)
D. Schilling (D)
Hsp70 binding to phosphatidylserine on pre-apoptotic tumor cells (10 mins)
H. Terunuma (J)
Regional hyperthermia induces an increase in a cytolytic NK cell subset and a decrease in a regulatory T cell subset (10 mins)
S. Das (USA)
Fast Optimization and Control in Electromagnetic Thermal Therapy Using Reduced Order Techniques (20 mins)
K. Kuroda (J)
Target-Tracking Thermometry for Focused Ultrasound Therapy of Liver based on Filtered Venography and Self-reference Techniques (20 mins)
Z. Cendes (USA)
Advances in Computer Modeling for Thermal Therapy and other Medical Applications (15 mins)
J. Lagendijk (NL)
The potential use of a 3T MRI for regional hyperthermia (15 mins)
K. Arunachalam (USA)
Characterization of Surface Thermometry Approaches for Clinical Hyperthermia (10 mins)
X. Chen (USA)
Treatment planning for catheter-based ultrasound hyperthermia in conjunction with HDR brachytherapy (10 mins)
12.00 – 12:15 Break
12.15 – 13:15 ESHO-BSD Award HS 6
13.15 – 14:45 LUNCH and POSTER VIEWING I
  View Poster Sessions here:
Physics/Technology
Immunology and HSP
Drug Delivery/Drug Targeting

General information:
Poster size 135 x 135 cm.
Poster outline should be concordant with the structure of the abstract submission.
Poster should be put up at 8:00 am and should be removed the same evening.
  Session III A – Thursday 14.45 – 16.15
Lecture room VI
Session III B – Thursday 14.45 – 16.15
Lecture room V
  Immunology II

Chair: S. Khleif (USA), E. Repasky (USA)
Treatment Planning and Image Guided Therapy I

Chair: P. Wust (D), C. Diederich (USA)
14:45 – 16:15 E. Repasky (USA)
Complex effects of hyperthermia on the immune system and implications for cancer therapy (15 mins)
S. Evans (USA)
Thermal targeting of vascular endothelial gateways to tumors(15 mins)
M. Di Nicola (I)
Vaccination of indolent non Hodgkin's lymphoma patients with autologous dendritic cells loaded with heat shocked and killed autologous tumor cells: a phase II study. (15 mins)
S. Khleif (USA)
Cancer vaccine, a promises or a reality (15 mins)
V. Milani (D)
Kinetic of initiation of an in vivo cytolytic response of NK cells against HSP70-positive tumor (15 mins)
S. Kokura (J)
Autologous Hsp70-rich tumor vaccine (15 mins)
P. Wust (D)
Standards for non-invasive control, planning and performance of regional hyperthermia (20 mins)
N. Kuster (CH)
Easy-to-use, real-time & reliable hyperthermia treatment planning: expectations & reality (20 mins)
C. Diederich (USA)
3D-Control of Thermal Therapy with Catheter-Based Ultrasound (20 mins)
S. Sprinkhuizen (NL)
Absolute MR thermometry using time domain analysis of the multi gradient-echo modulus Signal (10 mins)
E. Ebbini (USA)
Noninvasive temperature imaging using pulse-echo ultrasound: in vivo results (10 mins)
O. Craciunescu (USA)
Towards achieving accurate real time noninvasive volumetric temperature measurements uing magnetic resonance thermal imaging (MRTI) (10 mins)
16.15 – 16:30 Coffee Break
  Robinson Award HS 6
   

Chair: M. Hurwitz
16:30 – 17:30 J. Bull (USA)
Whole Body Thermal Therapy and Chemotherapy: Lessons Learned and Future Directions (60 mins)
  Business Meetings
17:30 – 18:30 HS 1
STM Business Meeting
HS 2
ESHO Business Meeting
HS 3
ASHO Business Meeting

Details
Friday, April 11th: Klinikum Grosshadern – Lecture Halls

  Session IV A – Friday 08.30 – 10.00 Lecture room VI Session IV B – Friday 8.30 – 10.00 Lecture room V
Time Clinic I: Gastrointestinal Cancer

Chair: S. Maluta (I), K. Tschoep (D)
Physiological Effects of Hyperthermia I

Chair: M. Horseman (DK), P. Vaupel (D)
8:30 – 10:00 S. Maluta (I)
Impact of hyperthermia combined with radiochemotherapy in locally advanced pancreatic cancer (15 mins)
R. Wessalowski (D)
Cancer in children - Indications for hyperthermia (15 mins)
K. Tschoep (D)
Gemcitabine (GEM) + cisplatin (CIS) combined with regional hyperthermia (RHT) in patients with GEM-pre-treated pancreatic cancer: Results of the ESHO phase II trial (15 mins)
H. Sakurai (J)
Clinical studies using Thermotron-RF8 for advanced lung, esophageal and rectal cancer -Gunma University experience- (15 mins)
B. Rau (D)
Thermotherapy of oesophageal cancer with paramagnetic nanoparticles (15 mins)
T. Takagi (J)
The effect of the combination therapy of hyperthermia and gemcitabine for the treatment of advanced inoperable pancreatic cancer (15 mins)
M. Horsman (DK)
Vascular based approaches for improving hyperthermia (20 mins)
P. Vaupel (D)
Impact of tumor hypoxia on the efficacy of hyperthermia: Help or hindrance? (20 mins)
R. Griffin (USA)
Mechanisms and Implications of Vascular Thermotolerance for Thermoradiotherapy (15 mins)
A. Sen (USA)
Fever-range whole body hyperthermia increases the efficacy of radiation therapy by selectively increasing the percentage of perfused tumor blood vessels (15 mins)
J. Roti Roti (USA)
Nucleophosmin\'s (NPM) Role in the Apparent Masking of DNA Damage when Measured by Two Assays (15 mins)
10.00 – 10:30 Coffee Break
  Session V A – Friday 10.30 – 12.00 Lecture room VI Session V B – Friday 10.30 – 12.00 Lecture room V
  Clinic II: Solid Tumors

Chair: R. Issels (D), M. Hurwitz (USA)
Physiological Effects of Hyperthermia II and Biological Modifiers of Thermal Response

Chair: R. Myerson (USA), A. Takahashi (J)
10:30 – 12:00 R. Issels (D)
Risk of early progression in patients with high-risk soft tissue sarcomas: results of the phase III randomized prospective trial of neoadjuvant chemotherapy with or without regional hyperthermia (EORTC-ESHO Intergroup trial) (20 mins)
R. Colombo (I)
Chemio-Hyperthermia for treatment of non-muscle invasive bladder cancer. An overview on basic science and clinical outcomes (20 mins)
M. Hurwitz (USA)
Hyperthermia For Prostate Cancer: Clinical Results and Future Directions (20 mins)
F. Pioli (I)
Outcomes and quality of life in patients affected by advanced rectal cancer treated with neoadjuvant radio-chemotherapy combined with hyperthermia (15 mins)
S. Zhang (PR China)
Clinical study of recombinant human p53 adenovirus combined with hyperthermia in advanced cancer ( a report of 32 cases ) (15 mins)
R. Myerson (USA)
Thermal Dosimetry Revisited (15 mins)
M. Dewhirst (USA)
Role of HIF-1 in response of tumor to hyperthermia (15 mins)
H. Park (KR)
Upregulation of NQO1 by heat-shock enhances the sensitivity of cancer cells to B-lapachone (15 mins)
K. Ohnishi (J)
Tween80 enhances heat-induced arrest of cell proliferation through regulating Akt and NBS1signaling pathways (15 mins)
T. Hasegawa (J)
Enhancement of hyperthermic effects using extracts from the mushroom (IWADE strain: grifola gargal) (15 mins)
T. Hori (J)
Anisomycin-induced apoptosis and its enhancement by mild hyperthermia (15 mins)
12.00 – 12:15 Break
  ASHO Award HS 6
  Chair: T. Ohnishi
12:15 – 13:15 Y. Harima (J)
Predictive cancer-related genes for effectiveness of hyperthermia oncology
13:15 – 14:45 LUNCH and POSTER VIEWING II
  View Poster Sessions here:
Physics/Technology
Drug Delivery/Drug Targeting

General information:
Poster size 135 x 135 cm.
Poster outline should be concordant with the structure of the abstract submission.
Poster should be put up at 8:00 am and should be removed the same evening.
  Session VI A – Friday 14.45 – 16.15 Lecture room VI Session VI B – Friday 14.45 – 16.15 Lecture room V
  Clinic III: Breast and Cervical Cancer

Chair: Z. Vujaskovic (USA), X. Shao (PR China)
Thermosensitive Liposomes and Intravital Microscopy

Chair: M. Dewhirst (USA) M. Yatvin (USA)
14:45 – 16:15 J. van der Zee (NL)
Results of a Cochrane review on hyperthermia in cervical cancer (15 mins)
M. Franckena (NL)
Long-term improvement in treatment outcome after radiotherapy and hyperthermia in locoregionally advanced cervix cancer: An update of the Dutch Deep Hyperthermia Trial (15 mins)
X. Shao (PR China)
Intracavitary hyperthermia combined with radiotherapy for the treatment of patients with stage Ib2 cervical cancer (10 mins)
M. Gabbani (I)
Clinical Impact of adding hyperthermia in patients affected by locally advanced cervical cancer treated with chemo-radiotherapy: the experience of Verona multidisciplinary group (10 mins)
K. Kiel (USA)
Hyperthermia and radiation therapy, with and without chemotherapy, for locally advanced or recurrent breast carcinoma (15 mins)
Z. Vujaskovic (USA)
An update of the duke experience for thermally sensitive (TS) liposomes containing doxorubicin (Thermodox, TDOX) in combination with hyperthermia (HT) in breast cancer patients with chest (cw) wall recurrence (15 mins)
Z. Vujaskovic (USA)
Neoadjuvant Hyperthermia and Chemotherapy for Locally Advanced Breast Cancer:Treatment (10 mins)
M. Dewhirst (USA)
An overview of progress in development of thermally sensitive liposomal drug delivery systems (30 mins)
L. Lindner (D)
Heat inducible cytotoxicity of hexadecylphosphocholine (miltefosine) in thermosensitive liposomes (12 mins)
M. Ogris (D)
Targeting of thermosensitive non-viral gene delivery vectors to tumors with locoregional hyperthermia (12 mins)
G. Koning (NL)
Development of an intravital microscopy setup to analyze tumor vascular responses during hyperthermia (12 mins)
A. Manzoor (USA)
Confocal microscopy of temperature-sensitive liposomes in-vivo: simultaneous imaging of the tumor microvasculature, the liposomes, and drug using three different fluorescent labels. (12 mins)
M. Peller (D)
MRI-monitoring of hyperthermia induced Gadodiamide release from long-circulating thermosensitive liposomes in tumors (12 mins)
16.15 – 16:30 Coffee Break
16:30 – 16:45 International Journal of Hyperthermia – Editor’s Awards
Friday 16:30 – 16:45 Lecture room VI
  Chair: M. Dewhirst (USA)
16:45 – 17:25 Young Investigator Travel Awards –
Presentation of all awardees and talk of the three best abstracts
Friday 16:45 - 17:25 Lecture room VI
  Chair: P. Stauffer (USA), O. Dahl (N)
16:45 – 17:15 S. Adachi (J)
Effect of pre-hyperthermia combined with gemcitabine on the apoptotic cell death in cultured human pancreatic cell lines (10 mins)
M. Wittlinger (D)
Organ-preserving, quadrimodal treatment of T1-2N0M0 bladder cancer: Late toxicity and quality of life after trans-urethral resection and simultaneous radiochemotherapy combined with regional deep hyperthermia (10 mins)
E. Mori (J)
Development of thermotolerance requires interaction between polymerase β and heat shock proteins (10 mins)
  Presentations of further awardees
17:15 – 17:25 M. Paulides (NL)
Application of hyperthermia in the head and neck using the hypercollar
M. Franckena (NL)
Radiotherapy and hyperthermia for treatment of primary locally advanced cervix cancer: results in 378 patients
S. Sprinkhuizen (NL)
Absolute MR thermometry using time domain analysis of the multi gradient-echo modulus signal
A. Manzoor (USA)
Confocal microscopy of temperature-sensitive liposomes in-vivo: simultaneous imaging of the tumor microvasculature, the liposomes, and drug using three different fluorescent labels.
T. Hori (J)
Anisomycin-induced apoptosis and its enhancement by mild hyperthermia
P. Prakash (USA)
Effect of blood-flow in large vessels on hepatic microwave ablation

Details
Saturday, April 12th: Klinikum Grosshadern – Lecture Halls

  Session VII A – Saturday 08.30 – 10.00
Lecture room VI
Session VII B – Saturday 08.30 – 10.00
Lecture room V
Time Thermal ablation and Nano-Thermal Therapies

Chair: A. Jordan (D), G. Ter Haar (NL)
Improved Technology for Hyperthermia/Thermal Therapy Delivery

Chair: G. van Rhoon (NL), K. Ito (J)
8:30 – 10:00 G. Ter Haar (NL)
High Intensity Focused Ultrasound (20 mins)
N. McDannold (USA)
MRI-guided focused ultrasound for thermal ablation and drug delivery (20 mins)
D. Haemmerich (USA)
Thermal ablation at radio- and audio-frequencies (15 mins)
A. Jordan (D)
Thermotherapy using magnetic nanoparticles: Principles and clinical application (20 mins)
A. Taylor (D)
Carbon Coated Nanomagnets as Potential Agents for Thermotherapy (15 mins)
G. van Rhoon (NL)
Innovation in devices and technology for hyperthermia (20 mins)
K. Ito (J)
Microwave interstitial and intracavitary hyperthermia (15 mins)
H. Kato (J)
Focused deep heating with annular-shaped inductive aperture-type applicator (15 mins)
S. Osinsky (RU)
Tumor hypoxia: whether it may be evaluated for prediction of the clinical outcome (10 mins)
P. Turner (USA)
Spiral arrays for superficial hyperthermia (10 mins)
J. Penagaricano (USA)
Performance evaluation of the scanning ultrasound linear array system (SURLAS) under a helical tomotherapy radiation fan beam (10 mins)
J. Wootton (USA)
Intrauterine ultrasound applicator for integrated hyperthermia and HDR brachytherapy in the management of locally advanced cervical carcinoma (10 mins)
10.00 – 10:30 Coffee Break
  Session VIII – Saturday 10.30 – 12.00
Lecture room VI
Time Summaries and closing
10:30 – 12:00 N. Huilgol (IND)
Clinical Hyperthermia: Opportunities and Challenges in developing countries (20 mins)
Y. Tanaka (J)
The past and present status of hyperthermic oncology in Japan (20 mins)
E. Repasky (USA)
Biology summary (7 mins)
M. Dewhirst (USA)
Physiology summary (7 mins)
P. Stauffer (USA)
Physics summary (7 mins)
G. van Rhoon (NL)
Technology summary (7 mins)
J. van der Zee (NL)
Clinics summary I (7 mins)
L. Lindner (D)
Clinics summary II (7 mins)
N.N.
Invitation to ICHO 2012 (5 mins)
R. Issels (D)
Farewell (5 mins)